Sandhya Prabhakaran

This study shows that stromal niches protect lung cancers from ALK inhibitors through multiple mechanisms, and targeting these mechanisms together is more effective than targeting them individually.

This study uses a mathematical model to show that ploidy and resource availability in the tumor microenvironment influence glioblastoma initiation and recurrence.

The paper integrates sequencing and imaging data to map cell cycle states, linking transcriptome states to living cells with high resolution.

The paper discusses challenges in digital image analysis of cancerous tissues and outlines solutions developed during a 2022 hackathon.

Sparcle reassigns transcripts to cells in multiplexed images using gene covariation and spatial features, improving quantification and cell boundary delineation without requiring accurate segmentation.

The paper introduces K-mer Motif Multinomial Mixtures (KMMMs), a Bayesian framework for motif discovery in sequence data, and applies it to DNAse hypersensitive sites and ChIP-seq peaks.