Elena Bossi

This paper shows that the LRRK2 G2019S mutation reduces GABA-evoked currents and disrupts the excitatory/inhibitory balance in the striatum.

The paper investigates isomer-specific responses of 3',5'- and 2',3'-cAMP in Arabidopsis, revealing distinct proteomic and physiological effects.

This study evaluates three MDMA bioisosteres for improved pharmacological profiles, finding reduced off-target receptor activity and altered hepatic metabolism compared to MDMA.

This study identifies betaine as a slow substrate of GAT1, showing it modulates GABA reuptake and helps maintain GABA homeostasis, protecting neurons from excitotoxicity.

This study shows that the LRRK2 G2019S mutation impairs EAAT2 trafficking, leading to reduced glutamate clearance and potential neurodegeneration in Parkinson's disease.

This study investigates how bile acid obeticholic acid (OCA) interacts with the dopamine transporter (DAT) and modulates its activity through non-competitive binding mechanisms.