Author

Brendan L. Horton

Massachusetts Institute of TechnologyORCID 0000-0002-9551-9002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Duncan M. MorganiD· 1 shared John Christopher LoveiD· 1 shared Maria ZagorulyaiD· 1 shared Richard VaniD· 1 shared Stefani SprangeriD· 1 shared Teresa DinteriD· 1 shared Vidit BhandarkariD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Duncan M. MorganORCID

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1 paper

Recent·Most cited

ImmunologyScience ImmunologyPeer-reviewedSep 13, 2024

Differentiation and Expansion of Tumor-Infiltrating T Cell Clonotypes Occurs in the Spleen Following Immune Checkpoint Blockade

Duncan M. Morgan, Brendan L. Horton, Vidit Bhandarkar…·Stefani Spranger

This study identifies spleen-resident intermediate-exhausted T cells as key to ICB efficacy, showing their expansion and differentiation into tumor-infiltrating clonotypes.

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