Herbert Waldmann

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

This study develops peptide-based tracers for SPSB2 E3 ligase by conjugating cell-penetrating peptides to degrons, enabling efficient cellular delivery and target engagement assessment.

The paper identifies small molecules that enhance NK cell tumoricidal activity by counteracting immunosuppressive factors in the tumor microenvironment using a co-culture assay.

The paper shows that the Cell Painting assay can detect mitochondrial stress and predict mitochondrial toxicity in small molecules.

The paper identifies epoxykynin as a potent sEH inhibitor that modulates the kynurenine pathway, offering new opportunities to address cancer-induced immune tolerance.