Scott Lovell

This paper introduces a new cyclisation strategy using a bromomethyl picolinaldehyde linker to expand macrocyclic peptide topologies, leading to more potent and diverse inhibitors.

This paper introduces covalent macrocyclic activity-based probes (cmABPs) that selectively target non-catalytic residues in serine proteases, demonstrating their effectiveness with plasma kallikrein and urokinase plasminogen activator.

This paper introduces a method using macrocyclic phage display to identify selective protease substrates, demonstrating its effectiveness with FAP and DPP4.

This paper identifies covalent cyclic peptide inhibitors targeting protein-protein interactions using phage display, demonstrating antiviral activity against SARS-CoV-2.

The paper identifies mixed alkyl/aryl phosphonates as anti-malarial compounds that inhibit serine hydrolases with low resistance potential.