Abdulrahman Salhab

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

ESMM improves epigenomic state annotation by integrating DNA methylation and chromatin marks, enhancing the detection of heterochromatic regions and regulatory element boundaries.

EpiSegMix improves chromatin state segmentation by using a flexible hidden Markov model with duration modeling, outperforming existing tools in predicting gene expression.

The paper investigates age-related changes in endothelial cells of mice, identifying gene and chromatin alterations linked to increased intracerebral hemorrhage risk.

The paper characterizes the epigenomic organization of the Paramecium macronuclear genome, revealing broad histone mark domains and unique transcriptional features.

GwEEP quantifies DNA modifying enzyme efficiencies using HPoxBS data, revealing dynamic changes in methylation and hydroxylation during cellular reprogramming and development.

The paper identifies aging-associated differences in vesicle-bound and freely circulating small regulatory RNAs in mice, showing tRNA fragments and miRNAs strongly correlate with aging.

The paper compares DNase I-Seq, ATAC-Seq, and NOMe-Seq to identify assay-specific features and their impact on chromatin accessibility and gene expression prediction.

The paper identifies DNA methylation differences in monozygotic twins discordant for multiple sclerosis, highlighting treatment effects and genetic confounders.

The paper identifies partially methylated domains (PMDs) as widespread epigenomic features across human and mouse cells, showing cell-type specificity and links to gene expression, replication timing, and proliferation.