Jin Qian

This paper identifies a microbiota-driven neuroepithelial circuit that promotes GEJ tumorigenesis through bile acid remodeling and bacterial metabolites.

The paper shows that gastrin loss activates a vagal reflex that promotes CCK2R+ stem cell expansion and preneoplasia in gastric inflammation.

This paper shows that sensory neurons form long-term inflammatory memory, enhancing gastric regeneration and tumor susceptibility after injury.

This study identifies Tff2+ progenitors in the gastric corpus as the primary source of SPEM and gastric cancer following injury, showing they can bypass metaplasia and progress directly to dysplasia.

This study identifies NTN1/NEO1 as a key driver of pancreatic tumorigenesis and metastasis by promoting cancer stemness, EMT, and nerve innervation.

This study shows that macrophage ferroptosis impairs Aspergillus killing in lung transplant recipients, increasing fungal infection risk.

The paper identifies a CGRP/Ramp1 axis-mediated interaction between nociceptive neurons and gastric cancer cells that promotes tumor progression.

This paper introduces MDBrainT, a DNA methylation-based deconvolution method to predict cell composition in brain tumor microenvironments, revealing distinct patterns across tumor types and molecular subtypes that correlate with patient outcomes.

This paper shows that a CXCR4 partial agonist enhances immunotherapy in gastric cancer by targeting PMN-MDSCs and granulopoiesis.