Yidan Pan

This study uses single-cell and spatial multi-omics to analyze a malignant peripheral nerve sheath tumor, revealing chromosomal instability drives phenotypic diversity and spatial-temporal evolution.

This paper demonstrates a magnetically gated CRISPR platform that spatially confines genome editing to target tissues, enabling localized immunotherapy in a murine tumor model.

Arborist improves tumor phylogeny reconstruction by integrating bulk DNA-seq and low-pass scDNA-seq data, outperforming existing methods on simulated and biological datasets.

The paper develops a Siamese convolutional neural network for CRISPR-Cas off-target scoring and shows that transfer learning improves performance on a curated benchmark dataset.

The paper introduces TRACE-Seq, a method to track clonal reconstitution of gene-targeted human hematopoietic stem cells using barcoded AAV6 donor templates in immunodeficient mice.