Gang Bao

The paper quantifies protein turnover in frog and fly embryos using 18O-water labeling and proteomics, revealing divergent strategies of maternal proteome inheritance.

This study encapsulates AAVs into protein vault nanoparticles to bypass neutralizing antibodies, enabling effective gene therapy despite preexisting immunity.

This paper introduces a dual-channel magnetic chamber for high-frequency magnetic neuromodulation in mice, capable of generating two independent magnetic fields with minimal interference and real-time behavioral monitoring.

This paper introduces a synergistic Lys-C/Arg-C Ultra digestion strategy to improve proteome coverage and quantitative reproducibility in shotgun proteomics.

This paper introduces a method to increase the proportion of correctly repaired hepatocytes in the liver through transient gene inhibition and transgene delivery, achieving a 25% increase in targeted cells and five-fold transgene expression.

The paper validates the effects of SNPs on gene expression in myeloid cells and finds that haplotype effects, not single variants, explain many associations.

This paper introduces a novel gene therapy platform using covalently linked adenovirus-AAV complexes to improve co-infection efficiency and reduce AAV dose requirements.

The paper develops a Siamese convolutional neural network for CRISPR-Cas off-target scoring and shows that transfer learning improves performance on a curated benchmark dataset.

The paper introduces TRACE-Seq, a method to track clonal reconstitution of gene-targeted human hematopoietic stem cells using barcoded AAV6 donor templates in immunodeficient mice.

This study uses CRISPR/Cas9 to edit hematopoietic stem cells to express iduronidase, correcting Mucopolysaccharidosis type I in mice.

This paper corrects the ΔF508 mutation in CF patient airway stem cells using CRISPR-Cas9 and AAV6, achieving high correction rates and functional rescue in differentiated epithelia.