Olga Ilkayeva

This study identifies SIRT4 as a lysine deitaconylase that regulates macrophage inflammatory responses and wound healing by modulating protein itaconylation in mice.

The paper identifies Complex II's role in de novo purine biosynthesis in AML using CRISPR and metabolomic data, showing it as a therapeutic target.

This study integrates transcriptomic and metabolomic analyses to reveal novel regulatory functions of ChREBP in mitochondrial metabolism and cellular energy balance beyond its canonical roles in carbohydrate and lipid metabolism.

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

This study identifies de novo lipogenesis as a critical source of fatty acids for autophagosome membrane dynamics in adipocytes, showing that Fasn deficiency impairs autophagy and p62 degradation.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.

The paper identifies distinct enhancer signatures in NASH-prone and NASH-resistant human obesity patients, revealing key genes and pathways associated with resistance.

This study shows that type 2 diabetes in vervet monkeys alters cerebrospinal fluid metabolites and amyloid levels, but not plasma metabolites or AD risk profiles.

The paper investigates how excess dietary sugar and fat affect liver mitochondria protein acetylation and succinylation in mice through multi-omic profiling.