Samir Softic

The paper shows cold acclimation increases n-3 HUFAs in the liver, reducing steatosis by altering lipid composition and metabolism.

This study shows that fructose's impact on metabolism depends on baseline diet, exposure duration, and sex in mice.

This study shows that liver-specific deletion of CPT1a in mice leads to reduced DHA-containing phospholipids and sexually dimorphic liver disease, with females showing more severe effects.

This study compares the effects of GalNAc-siRNA-mediated KHK knockdown and small molecule KHK inhibition on hepatic metabolism in mice on a high-fat diet, finding divergent impacts on lipid metabolism and glucose tolerance.

This study shows that fructose metabolism via KHK-C increases ER stress and modulates the hepatic transcriptome, contributing to NAFLD progression in both genetic and diet-induced models.

The paper investigates how excess dietary sugar and fat affect liver mitochondria protein acetylation and succinylation in mice through multi-omic profiling.