Author

Lancia N. F. Darville

Moffitt Cancer CenterORCID 0000-0002-9793-3741Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:metabolomics· 1

Frequent Co-Authors

John M. KoomeniD· 2 shared Avani A. DeshpandeiD· 1 shared Bin FangiD· 1 shared Brittany R. Evernden· 1 shared Daniel Abate‐DagaiD· 1 shared Elena Martinez PlanesiD· 1 shared Elsa Renee FloresiD· 1 shared Fredrick L. Locke· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

John M. KoomenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 15, 2026

TAp63-regulated oncogenic long non-coding RNA-8 ( TROLL-8 ) regulates human breast cancer progression through CPT1A-mediated fatty acid oxidation

Avani A. Deshpande, Marco Napoli, John H. Lockhart…·Elsa Renee Flores

This study identifies TROLL-8 as a regulator of fatty acid oxidation in breast cancer, showing its role in promoting tumorigenesis through CPT1A interaction.

DOI 10.64898/2026.06.11.731679

humanproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 1, 2026

C-terminus CD28 phosphorylation (Y218) modulates IL-2 secretion and antitumor effect of CAR-T cells

Elena Martinez Planes, Maria Cecilia Ramello, Miguel Gomez Fontela…·Daniel Abate‐Daga

This study identifies Y218 phosphorylation in CD28 as critical for IL-2 secretion and antitumor efficacy of CAR-T cells, showing that enhancing ITK recruitment improves therapeutic outcomes.

DOI 10.64898/2026.01.28.701378

humanproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 18, 2023

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

Mariam Lotfy Khaled, Yuan Ren, Ronak Kundalia…·Inna Smalley

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky