Giedrė Tamulaitienė

This study identifies Csx15 as a ring nuclease that degrades cyclic nucleotides from both CRISPR-Cas and CBASS systems, revealing its role in regulating signaling pathways.

The paper identifies small molecule inhibitors of the Thoeris antiphage immune system in bacteria, showing that persistent immunity is required to prevent phage revival and population collapse.

This study reveals the structure of the type II-A CRISPR-Cas prespacer selection supercomplex and elucidates the role of Csn2 in Cas9-mediated spacer acquisition.

This study identifies chemical inhibitors that block a bacterial immune system, enhancing phage therapy efficacy against resistant strains.

The paper shows that deoxydinucleotides activate the bacterial anti-phage defense system ApeA by binding to a conserved pocket, enabling broad protection against phage infection.

The paper identifies His-ADPR as a novel TIR-derived immune signaling molecule in bacteria, showing its role in phage defense and structural basis for recognition.

The paper characterizes the CRISPR SAVED-Lon system, showing that filament formation activates protease and ring nuclease activities, leading to growth arrest in E. coli.