Arūnas Šilanskas

This study shows that viral SSB-bound ssDNA activates the bacterial anti-phage defense system DARNA by recognizing a signal promoted by viral proteins, enabling broad virus detection without auto-immunity.

This study reveals the structure of the type II-A CRISPR-Cas prespacer selection supercomplex and elucidates the role of Csn2 in Cas9-mediated spacer acquisition.

The paper shows that deoxydinucleotides activate the bacterial anti-phage defense system ApeA by binding to a conserved pocket, enabling broad protection against phage infection.

The paper identifies His-ADPR as a novel TIR-derived immune signaling molecule in bacteria, showing its role in phage defense and structural basis for recognition.

The paper reveals a beta-relay signaling mechanism in prokaryotic Argonautes that activates the SPARDA defense system to degrade invading DNA and host DNA, preventing plasmid spread.

The paper shows short prokaryotic Argonautes, when associated with Sir2, deplete NAD+ to defend against invading DNA.