Cancer BiologyNucleic Acids ResearchPeer-reviewed
ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer
Chen Qian, Qian Yang, Mirja Rotinen…·Michael R. Freeman
This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.
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