Michael R. Freeman

This study shows that large oncosomes reprogram bone marrow mesenchymal stem cells to create a pre-metastatic niche by inducing an interferon-driven inflammatory response.

This study compares QuPath and HALO for analyzing prostate cancer tumor microenvironment using multiplex immunofluorescence data, finding high concordance and demonstrating QuPath's flexibility.

This study provides a multiomics resource of cancer extracellular vesicles, showing correlations between LO proteins and prostate cancer progression, and demonstrating the feasibility of single-cell RNA-Seq on EVs.

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

This study identifies RARγ's role in bookmarking AR enhancer interactions in prostate cancer, showing its impact on enzalutamide sensitivity and lineage plasticity.

This study uses multi-omics to show ONECUT2 restricts M cell differentiation in mouse intestinal organoids by acting downstream of RANK/RANKL signaling.