Angela M. Phillips

This study quantifies biophysical trade-offs in antibody evolution by analyzing surface expression, affinity, and self-reactivity across 213 evolutionary intermediates of a SARS-CoV-2 antibody lineage.

This study compares adaptive routes in two yeast species after 10,000 generations, finding parallel but distinct molecular mechanisms of adaptation.

The paper shows that reference-free analysis is equivalent to reference-based methods, leading to identical landscapes but different interpretations of epistasis.