NeuroscienceFrontiers in PharmacologyPeer-reviewed
Loss of SynDIG4/PRRT1 alters distribution of AMPA receptors in Rab4- and Rab11-positive endosomes and impairs basal AMPA receptor recycling.
This study shows that SynDIG4 deficiency reduces GluA1 and GluA2 recycling, increases their internalization, and disrupts Rab4-Rab11 endosomal trafficking, impairing synaptic AMPAR distribution and function.
3 citations