BiochemistrybioRxivPreprint
In mitochondrial disease respiratory complex III2 assembles complex I via toxic intermediate
Maria G. Ayala-Hernandez, Anetzy Bermudez Torales, Hannah Camille Tan…·James A. Letts
The paper identifies toxic intermediate complexes formed during mitochondrial complex I assembly in NDUFS4 mutant mice, revealing hypoxia's role in rescuing disease by preventing pathological reverse electron transfer.
DOI 10.1101/2025.06.17.660237