Brian W. Pogue

This study shows that moderate and low tissue oxygen levels reduce radiation toxicity in murine skin under ultra-high dose rates but not conventional rates, with no FLASH sparing under anoxia or hyperoxia.

This study shows that anesthesia type affects the effectiveness of ultra-high dose-rate FLASH irradiation in sparing normal tissue in mice, with ketamine/xylazine preserving sparing while isoflurane abolishes it.

This paper visualizes lymphatic dynamics using transient hypoxia imaging in mice, showing hypoxia in lymph nodes and altered pumping frequency with tissue damage.

This study investigates how anesthetic oxygen use and sex affect the FLASH sparing effect in mice, finding that 100% oxygen reduces FLASH sparing and females show greater ulceration than males under oxygen.