Kourosh Hayatigolkhatmi

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

This paper identifies S166 phosphorylation on LSD1 as a regulatory switch that controls gene activation, chromatin remodeling, and tumor microenvironment in non-hormonal cancer cells.

This paper introduces an automated method for analyzing the cell cycle in both adherent and non-adherent cells using machine learning, validated in AML cell lines and drug response testing.