Vinay Swaminathan

The paper shows epithelial monolayers converge to the same final size and density after release from confinement, regardless of initial conditions, through mechanical pressure signaling.

This study shows that prolonged exposure to stiff ECM activates fibroblasts through integrin and formin pathways, leading to persistent activation and fibrosis, with chromatin remodeling playing a key role.

This study identifies a non-catalytic role of METTL3 in regulating exocytosis and the cancer secretome through stabilization of EXOC7.

This study shows that local cell packing fraction, not adhesion or stiffness, drives YAP activation in multicellular collectives, independent of single-cell mechanisms.

This paper introduces an algorithm to reconstruct 3D molecular orientation and density from polarized fluorescence microscopy data, demonstrating its application on biological structures and dynamics.

The paper introduces a polarized dual-view light-sheet microscope to recover 3D orientations and positions of fluorescent dipoles, validated with experiments on biological samples.

The paper develops iMSOD-mito, a tool to model human mesenchymal-to-hematopoietic mitochondrial transfer, showing preferential transfer to hematopoietic stem cells and functional impacts.

This study shows Septin-7 is an FA protein regulated by ECM and integrin activation, which differentially regulates FA subpopulations to promote mechanosensing and ECM remodeling in fibroblasts.

This paper introduces data-driven microscopy (DDM), a framework that enhances imaging fidelity by combining population-wide characterization with adaptive imaging techniques.

The paper shows that actin retrograde flow aligns and orients ligand-bound integrins in focal adhesions through force-induced structural changes.