Dominic Esposito

This study develops an in vitro BRAF activation assay to elucidate molecular mechanisms of BRAF disassembly and identifies RAS binding as critical for activation.

This study shows cancer stem cells (CSCs) have distinct population dynamics and are hyper-responsive to microenvironmental cues, which regulate metastasis and therapy response via the YAP/TAZ/TEAD pathway.

This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.

This study investigates the assembly of SARS-CoV-2 nucleocapsid protein with nucleic acids using biophysical techniques and mutant proteins, revealing key interaction motifs and stabilization mechanisms.

This paper develops potent humanized nanobodies against SARS-CoV-2 spike protein, showing effectiveness against the Alpha variant and providing structural insights into their neutralization mechanism.

The paper describes modified E. coli strains that block native Tn7 attachment sites to reduce contamination from non-recombinant baculovirus production.