Richard A. Dean

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

This paper introduces selective NaV1.6 and dual NaV1.6/NaV1.2 inhibitors that suppress excitatory neuronal activity ex vivo, showing selectivity over NaV1.1 and efficacy in seizure models.

The paper introduces an application to visualize mutations on voltage-gated sodium channels using D3.js, enabling customization and high-quality figure creation for genotype/phenotype studies.