Jeffrey A. Cole

This study characterizes SeaB, a Type 5a secretion system protein in Salmonella enterica, showing its role in biofilm formation, virulence, and protective immunity in a mouse model.

The paper analyzes whole genome sequences of Neisseria gonorrhoeae isolates from the G-ToG trial to characterize gonococcal diversity and AMR patterns in England, showing sexual network-driven phylogenetic structure and AMR differences between transmission groups.

The paper identifies that a high IgG2:IgG3 antibody ratio inhibits complement-mediated killing of Neisseria gonorrhoeae, revealing a mechanism for bacterial resistance.

This study validates a modified Gram stain technique to identify mucosal tissue with high bacterial biomass for downstream microbiota analysis, improving reproducibility and reducing noise in sequencing studies.

This study investigates the spatial organisation of gastric microbiota in health and disease, finding that non-H. pylori bacteria invade the lamina propria in H. pylori-associated gastric carcinogenesis.

TraDIS-validate is a method to validate ordered gene-replacement libraries, achieving 99.7% accuracy in identifying correct kanamycin cassette positions in the Keio library.

This study shows that MCE domains in Salmonella Typhimurium are essential for bile resistance and virulence, not for cell entry or adherence.