Shiqian Shen

The paper discovers abundant nanoscale lymphatic-like vessels in brain parenchyma of mice and humans, suggesting a previously unrecognized system for metabolic waste clearance.

The paper identifies an AAV capsid, MC5, that efficiently and specifically transduces microglia via direct and intracerebroventricular injection in mice.

This paper develops chemiluminescence probes for in vivo 3D brain imaging in Alzheimer's disease models, showing high photon emission and binding to amyloid beta.

This paper demonstrates the use of bioluminescence imaging with AkaLumine to report amyloid beta levels in Alzheimer's disease models and shows its potential for monitoring disease progression and therapy.