Author

Miguel C. Santoscoy

Harvard UniversityORCID 0000-0003-0249-4529Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Carrie Ng· 3 shared Casey A. MaguireiD· 3 shared Demitri de la Cruz· 3 shared Paula EspinozaiD· 3 shared Killian S. HanloniD· 2 shared Ming Liang ChengiD· 2 shared Ana Griciuc· 1 shared Boram LeeiD· 1 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBioengineering

Carrie Ng

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Author profile →

3 papers

Recent·Most cited

BioengineeringbioRxivPreprintSep 25, 2024

Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice

Miguel C. Santoscoy, Paula Espinoza, Killian S. Hanlon…·Casey A. Maguire

The paper identifies an AAV capsid, MC5, that efficiently and specifically transduces microglia via direct and intracerebroventricular injection in mice.

2 citations

mouseexperimental assay

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BioengineeringMetabolic EngineeringPeer-reviewedAug 19, 2024

Metabolic engineering improves transduction efficiency and downstream vector isolation by altering the lipid composition of extracellular vesicle-enclosed AAV.

Paula Espinoza, Ming Liang Cheng, Carrie Ng…·Miguel C. Santoscoy

6 citations

humanmouse

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BioengineeringMolecular TherapyPeer-reviewedJun 5, 2024

In vivo selection in non-human primates identifies superior AAV capsids for on-target CSF delivery to spinal cord

Killian S. Hanlon, Ming Liang Cheng, Roberto Montoro Ferrer…·Casey A. Maguire

The paper identifies superior AAV capsids for targeted spinal cord gene therapy in non-human primates through in vivo selection and evaluates their biodistribution and expression.

14 citations

non-human primateexperimental assay

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