Jichuan Wu

This paper identifies pulmonary neutrophils as the primary target of Abraxane in lung cancer and shows that its efficacy depends on complement pathway-mediated lung uptake.

This study shows that targeting DNA-LNPs to endothelial cells enhances transgene expression magnitude, duration, and specificity in target organs.

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

The paper identifies a critical threshold in complement activation based on surface density, showing percolation-type behavior in immune responses to materials.

This paper introduces multi-stage-mixing (MSM) to control lipid nanoparticle (LNP) supramolecular structure, creating a core-then-shell arrangement that significantly improves mRNA and DNA-LNP performance.

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

This paper combines affinity moiety targeting and physicochemical tropism in lipid nanoparticles to enhance organ targeting, showing improved specificity and uptake in lungs and brain.