Spyros A. Kalams

The paper shows that reduced mitochondrial respiratory capacity in myeloid cells during Mtb infection impairs immune function and Mtb control, with similar findings in human data.

This study finds that older adults have reduced antiviral CD4+ T and myeloid cell responses to influenza vaccines despite equivalent antibody titers, suggesting the need for vaccines targeting myeloid cell responses.

The paper isolates glycan-reactive antibodies from HIV-1 vaccine trial participants and finds they neutralize diverse HIV strains and show broad cross-reactivity against other pathogens.

The paper identifies adaptive-like NK cells in influenza responses linked to humoral immunity and influenced by age and sex, suggesting potential vaccine strategies for aging populations.

This study identifies genetic risk factors for tuberculosis in Brazil using GWAS and single-cell transcriptomics, finding SNPs associated with gene expression in multiple cell types.

The paper uses multiomic single-cell sequencing to analyze SJS/TEN patients' skin and blister fluid, identifying tissue-specific immune responses and T-cell clonotypes involved in pathogenesis.