Author

Michael A. Lyons

Colorado State UniversityORCID 0000-0003-0143-6626Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Approach:experimental assay· 1

Frequent Co-Authors

Andrés Obregón‐HenaoiD· 2 shared Gregory T. RobertsoniD· 2 shared Karen RossmassleriD· 2 shared Michelle E. Ramey· 2 shared Nicholas D. WalteriD· 2 shared Allie Bauman· 1 shared Allison A. BaumaniD· 1 shared Anne J. M. Lenaerts· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersGenomics

Andrés Obregón‐HenaoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintFeb 24, 2025

Deconvoluting drug interactions based on M. tuberculosis physiologic processes:Transcriptional disaggregation of the BPaL regimen in vivo

Elizabeth A. Wynn, Christian Dide-Agossou, Reem Al Mubarak…·Nicholas D. Walter

The paper uses SEARCH-TB to analyze drug interactions in M. tuberculosis by measuring transcriptional responses to the BPaL regimen in vivo, showing complex effects of drug combinations.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewedSep 30, 2024

Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis

Allison A. Bauman, Jansy Passiflora Sarathy, Firat Kaya…·Gregory T. Robertson

This study shows that MBX-4888A, a spectinamide, shortens tuberculosis treatment in murine models by improving tissue distribution and working well with rifampin and pyrazinamide.

6 citations

mouseexperimental assay

𝕏 PostBluesky

Pharmacology & ToxicologyAntimicrobial Agents and ChemotherapyPeer-reviewedMar 19, 2024

Use of Multiple Pharmacodynamic Measures to Deconstruct the Nix-TB Regimen in a Short-Course Murine Model of Tuberculosis

Michael A. Lyons, Andrés Obregón‐Henao, Michelle E. Ramey…·G. T. Robertson

The paper evaluates the Nix-TB regimen in a murine TB model using pharmacodynamic markers to assess drug contributions and interactions.

11 citations

mousebulk RNA-seq

𝕏 PostBluesky