J.R. Keown

This study characterizes the MERS-CoV replication-transcription complex and shows its structural similarity to SARS-CoV-2, with cross-species compatibility highlighting evolutionary conservation and virus-specific adaptations.

This study characterizes the structure and function of CCHFV RNA-dependent RNA polymerase, revealing its unique features and antiviral susceptibility.

The paper investigates the ester bond crosslinking mechanism in bacterial adhesin proteins, confirming a protease-like mechanism through structural, functional, and computational analyses.

This study uses smFRET to analyze SARS-CoV-2 RNA polymerase inhibitors, revealing remdesivir's mechanism involves polymerase stalling and chain termination.

This study identifies 5-methyl-3'-dUTP as a nucleoside analogue that effectively terminates SARS-CoV-2 RNA synthesis while resisting exonuclease proofreading.

This study characterizes the structural and functional interaction between influenza A virus RNA polymerase and host RNA Polymerase II CTD, identifying key residues and their roles in transcription and replication.