Christos Chinopoulos

This study shows that malignant glioma cells rely on amino acid and glucose fermentation for ATP production, not oxidative phosphorylation, and that glutamine is essential for maintaining ATP content and viability.

The paper correlates protein expression from RPPA with transcriptome data from public repositories in breast and kidney cancer samples, finding weak correlations between protein and gene expression.

The paper shows adult human astrocytes lack key mitochondrial proteins needed for oxidative phosphorylation, leading to lactate production instead of OXPHOS.