Author

Fangyuan Cao

Imperial College LondonORCID 0000-0003-0189-7764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Edward W. TateiD· 3 shared Andreas DamianouiD· 1 shared Anouk M. La RoseiD· 1 shared Athina Grigoriou· 1 shared Benedikt Mathias KessleriD· 1 shared Bin LiuiD· 1 shared Chloe Huang· 1 shared Christopher W. am EndeiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMolecular Biology

Edward W. TateORCID

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Author profile →

4 papers

Recent·Most cited

Molecular BiologyJournal of the American Chemical SocietyPeer-reviewedJun 10, 2025

Identification of actionable targeted protein degradation effector sites through Site-specific Ligand Incorporation-induced Proximity (SLIP)

Zhangping Xiao, Efthymios-Spyridon Gavriil, Fangyuan Cao…·Edward W. Tate

The paper introduces a chemical-genetic platform called SLIP to identify actionable sites on effector proteins for targeted protein degradation.

17 citationstop 3%

experimental assay

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BiochemistryCell ReportsPeer-reviewedApr 25, 2024

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

Zhu Liang, Andreas Damianou, Iolanda Vendrell…·Benedikt Mathias Kessler

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

40 citationstop 4%

humanproteomics

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Systems BiologybioRxivPreprintSep 28, 2022

Electrophile scanning by chemical proteomics reveals a potent pan-active DUB probe for investigation of deubiquitinase activity in live cells

Daniel Conole, Fangyuan Cao, Christopher W. am Ende…·Edward W. Tate

The paper identifies a small molecule DUB probe, IMP-2373, that quantitatively engages multiple DUBs in live cells and demonstrates its use in studying DUB activity changes during MYC deregulation.

DOI 10.1101/2022.09.28.509970

experimental assay

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GenomicsNucleic Acids ResearchPeer-reviewedNov 21, 2019

Inhibition of Histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing

Bin Liu, Siwei Chen, Anouk M. La Rose…·Hidde J. Haisma

The paper shows that inhibiting HDAC1 and HDAC2 improves CRISPR/Cas9 gene editing efficiency by opening chromatin and enhancing Cas9 access.

371 citationstop 1%

experimental assay

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