Author

Heather Cook

University of ExeterORCID 0000-0003-0223-417XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Ahmad AlaltiiD· 2 shared Andrew S. MasoniD· 2 shared Dawn CoverleyiD· 2 shared Emma StewartiD· 2 shared Ernesto López de AlbaiD· 2 shared Gabrielle L. TurveyiD· 2 shared Justin AinscoughiD· 2 shared Alfred A. AntsoniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCell Biology

Ahmad AlaltiORCID

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2 papers

Recent·Most cited

Cell BiologyThe Journal of Cell BiologyPeer-reviewedFeb 18, 2025

Epigenetic deprogramming driven by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers

Gabrielle L. Turvey, Ernesto López de Alba, Emma Stewart…·Dawn Coverley

The paper shows that elevated CIZ1 C-terminal anchor domain in early-stage breast cancers disrupts nuclear RNA assemblies, leading to chromatin deprotection and gene expression changes.

5 citations

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintSep 22, 2023

Dominant CIZ1 fragments drive epigenetic instability and are expressed in early stage cancers

Gabrielle L. Turvey, Ernesto López de Alba, Emma Stewart…·Dawn Coverley

This study identifies that elevated CIZ1 anchor domain fragments in early stage cancers disrupt SMACs, leading to epigenetic instability by destabilizing PRC1-dependent histone modifications.

2 citations

humanmouse

𝕏 PostBluesky