Ernesto López de Alba

This study presents a comprehensive catalog of human double-strand break repair genes using genome-wide knockout data, revealing novel mechanisms and factors involved in DSB repair.

The paper shows that elevated CIZ1 C-terminal anchor domain in early-stage breast cancers disrupts nuclear RNA assemblies, leading to chromatin deprotection and gene expression changes.

This study identifies that elevated CIZ1 anchor domain fragments in early stage cancers disrupt SMACs, leading to epigenetic instability by destabilizing PRC1-dependent histone modifications.