Cell BiologyPLoS BiologyPeer-reviewed
RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention
Patricia M. dos Passos, Erandika H. Hemamali, Lohany Dias Mamede…·Yuna M. Ayala
This study shows that RNA-mediated TDP-43 self-assembly forms macromolecular complexes that retain TDP-43 in the nucleus, preventing cytoplasmic aggregation and highlighting potential therapeutic targets.
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