Author
Saint Louis University
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Azamat Rizuan, Jayakrishna Shenoy, Priyesh Mohanty…·Nicolas Lux Fawzi
This study investigates the structural basis of TDP-43 C-terminal domain multimerization using biophysical experiments, AlphaFold2-Multimer, and simulations, revealing helical oligomerization and the role of specific residues in phase separation and disease.
Lohany Dias Mamede, Miwei Hu, Amanda R. Titus…·Yuna M. Ayala
This study shows that TDP-43 aggregation through prion-like seeding impairs its autoregulation, leading to dysfunction and loss of function in cells.
Patricia M. dos Passos, Erandika H. Hemamali, Lohany Dias Mamede…·Yuna M. Ayala
This study shows that RNA-mediated TDP-43 self-assembly forms macromolecular complexes that retain TDP-43 in the nucleus, preventing cytoplasmic aggregation and highlighting potential therapeutic targets.