Helle Krogh Johansen

This study compares antibiotic response phenotypes of Pseudomonas aeruginosa isolates under standard lab conditions and in an airway epithelial model, finding discordant results for some isolates.

This study shows that antibiotic selection in a human airway tissue model of Pseudomonas aeruginosa leads to evolution of less virulent, tissue-preserving infections with enhanced survival.

The paper uses a human airway model to study co-infection dynamics between Staphylococcus aureus and Pseudomonas aeruginosa, revealing strain-specific traits and secretion systems that influence microbial competition.

This study analyzes the evolution of Achromobacter ruhlandii over 30 years, identifying genomic features associated with epidemic potential and chronic infections.

The paper uses a mung bean model to compare virulence of Pseudomonas aeruginosa CF isolates and analyze transcriptional changes during infection.

This study shows that macrophages alter cytokine responses and bacterial spatial organization in airway epithelial cultures without changing bacterial burden.

This study shows that OprD mutations in Pseudomonas aeruginosa enhance bacterial attachment and translocation across airway epithelial barriers, altering infection dynamics beyond antibiotic resistance.

This study shows that removing glycosaminoglycans from extracellular vesicles increases their uptake and cargo delivery to target cells, suggesting glycan structures can be tuned for better drug delivery.

This paper develops a dual-cell air-liquid interface model to study epithelial-immune interactions during airway infection, finding that macrophages modulate inflammation and bacterial distribution.

The paper identifies pyruvate cross-feeding as a mechanism enabling Pseudomonas aeruginosa persistence in chronic infections by modulating host immune responses and oxidative stress.

This study uses fluorescent reporters to analyze Pseudomonas aeruginosa growth activity in human airway epithelial models, revealing strain-specific colonization patterns and growth hierarchies across infection niches.

The paper investigates infection dynamics and virulence of Pseudomonas aeruginosa in human airway epithelial models, identifying four infection clusters based on strain-specific virulence and host response.

This study shows that macrolides are effective against Pseudomonas aeruginosa in airway infections but lead to resistance via uL4 and uL22 ribosomal mutations, requiring higher antibiotic concentrations and reducing bacterial fitness.

This study identifies a specific immune profile in cystic fibrosis patients linked to lung microbiota and immune dysregulation, offering potential targets for treatment.

This study shows that mexZ mutations in Pseudomonas aeruginosa lead to antibiotic tolerance and altered colonization in human airway models through overexpression of lecA.

This study tracks Pseudomonas aeruginosa evolution in 9 cystic fibrosis patients over decades, finding phenotypic convergence despite genomic divergence and reduced virulence features.

This study characterizes antibiotic resistance in Danish Klebsiella pneumoniae isolates, finding differences in AMR profiles and virulence compared to global strains.

The paper analyzes Achromobacter infections in cystic fibrosis patients using whole-genome sequencing to identify transmission patterns and antibiotic resistance development.