Kristianne Michelle Oristian

This study identifies CDK8 inhibition as a therapeutic strategy for alveolar rhabdomyosarcoma by inducing myogenic differentiation and impairing tumor growth through a mechanism involving the Mediator kinase module, SAGA complex, and SIX4.

This paper shows serum pro-N-cadherin levels correlate with cardiac fibrosis and diastolic dysfunction in irradiated non-human primates, suggesting it as a potential biomarker for radiation-related heart disease.

This paper develops a new mouse model of CIC::DUX4 sarcoma and identifies Minnelide as a selective inhibitor effective in preclinical models.

This study generates genetically engineered mouse models of CIC-DUX4 sarcoma that spontaneously develop tumors and express the fusion protein, validating CIC-DUX4 as a transcriptional activator.