Noriaki Sasai

The paper uses a stepwise Bayesian framework to identify a novel gene regulatory network component in neural tube development using whole-genome sequencing data from neural precursor cells treated with Sonic Hedgehog.

The paper investigates how Hedgehog signaling and transcription factors regulate hypothalamic regionalization during development.

This study shows that heterozygous ZBTB38 loss in mice causes early embryonic lethality by reducing Nanog and Sox2 expression, while ZBTB38 is not essential for ES cell establishment.

This study identifies Edn2 upregulation in Prom1-deficient mice and shows that endothelin receptor antagonists reduce retinal degeneration.

This study identifies RNF152 as a negative regulator of mTOR signaling in the floor plate, which blocks cell proliferation and controls cell number.

This study shows Prom1 triggers membrane protrusions via Rho/ROCK signaling and chloride efflux, independent of actin/tubulin polymerization.

This study identifies GPR17 as a negative regulator of the Sonic Hedgehog signaling pathway in neural tube development, showing its role in temporal regulation and feedback inhibition.