Vı́tězslav Bryja

This study identifies SorCS2 as a regulator of Wnt signaling homeostasis by controlling Ror2 trafficking and signaling, with implications for neurodevelopment.

This study identifies the molecular mechanisms underlying the functional divergence of CK1 paralogs in the Wnt pathway, showing how CK1 and CK1δ/ε have distinct roles and affinities for substrates and complexes.

This study identifies CK1-mediated phosphorylation of NOTCH1 at S1970 as essential for its transcriptional activity and signaling in vivo.

The paper identifies a Wnt-induced phospho-switch in DVL3 that regulates its interaction with Frizzled receptors and Wnt/β-catenin signaling through conformational changes.

This study identifies two mechanisms by which RECQ5 modulates RNA polymerase II transcription: attenuating elongation via the brake helix and forming a condensate scaffold matrix.

The paper identifies RAI14, EPHA2, and PHACTR4 as essential components of the Wnt/PCP pathway in vertebrates through BioID and zebrafish loss-of-function studies.

This study identifies DVL2 oligomer formation as essential for Wnt/β-catenin signaling, revealing two-step condensate formation through high- and low-affinity interaction sites.

The paper identifies sex differences in bleeding risk and explores non-invasive vascular analysis in Alagille syndrome using mouse models and retinography.

LuminoCell is an affordable, open-source luminometer platform for real-time monitoring of in-cell luciferase activity in various biological assays.

This study constructs a single-cell and spatial atlas of the choroid plexus in developing and adult mice, revealing cell types, regional gene expression, and cell-cell interactions.

This study identifies the MEIS-WNT5A axis as critical for the development and morphology of the fourth ventricle choroid plexus.