Probing RNA-protein interactions in the early mouse embryo
The paper adapts REMORA to study RNA-binding protein functions in early mouse embryos, identifying direct regulatory roles for several RBPs, including Alyref in 3' polyadenylation control.
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University of South Bohemia in České BudějoviceORCID 0000-0002-8400-5380Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
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The paper adapts REMORA to study RNA-binding protein functions in early mouse embryos, identifying direct regulatory roles for several RBPs, including Alyref in 3' polyadenylation control.
Lenka Gahurová, Jana Tománková, Pavlina Cerna…·Alexander W. Bruce
The paper identifies mTORC1 and 7mG-cap dependent translation as regulators of spatial positioning of blastomeres during the 8- to 16-cell transition in mouse embryos.
Pablo Bora, Lenka Gahurová, Andrea Hauserová…·Alexander W. Bruce
This study investigates the role of DDX21 in mouse preimplantation embryo development, showing its necessity for cell-fate specification and blastocyst formation through p38-MAPK regulation.
Martin Pospíšek, Alexander W. Bruce, Pablo Bora…·Anna Ajduk
This study shows that p38-MAPK regulates PrE differentiation during mouse blastocyst maturation by controlling translation and rRNA processing through Mybpp1a.
Giorgio Virnicchi, Pablo Bora, Lenka Gahurová…·Alexander W. Bruce
This study identifies Wwc2 as a regulator of cell division during mouse preimplantation embryo development and oogenesis, showing its role in maintaining cell number and division fidelity.
Pablo Bora, Vasanth Thamodaran, Andrej Šušor, Alexander W. Bruce
The paper shows that p38-MAPK regulates blastocyst development in response to amino acid availability and oxidative stress, affecting cell lineage specification and blastocyst size.