Werner Schmitz

This study identifies a heme-HMOX1-ferritin axis that protects cells from ferroptosis by stabilizing heme and upregulating ferritin when HMOX1 is inactive.

This study shows that arginine depletion induces senescence and stress response in pancreatic cancer cells, making them susceptible to senolysis and stress response inhibition.

This study shows L-asparaginase reduces B cell proliferation and function, induces a regulatory B cell phenotype, and may have immunosuppressive effects on non-malignant B cells.

This study shows that MYC suppresses lysosomal protein degradation in pancreatic ductal adenocarcinoma, promoting immune evasion by altering amino acid availability and immune cell responses.

This study shows that melphalan treatment causes oxidative stress in T cells, reducing CD4+ naive T cells in high-risk multiple myeloma patients.

This study shows that Tafazzin-mediated cardiolipin remodeling is essential for metabolic stress response and effector function of inflammatory T cells, with implications for Barth syndrome.

This study assesses neurobehavioural traits in axenic mice to evaluate the impact of microbiota on anxiety-like behaviour and memory over time.

This study shows that methionine restriction reduces proliferation in multiple myeloma cell lines without causing cell death, suggesting it as a potential cancer therapy.

This study identifies riboflavin as a modulator of ferroptosis sensitivity by supporting FSP1 stability and antioxidant recycling, with implications for therapeutic targeting.

This study identifies the LutACB operon's role in Neisseria gonorrhoeae resistance to neutrophil-mediated oxidative stress by linking lactate utilization to sulfur metabolism.

This study shows that glucose uptake via GLUT1/3 is essential for neutrophil oxidative burst and lipid mediator production during microbial infection.

This study identifies HIF-1α-mediated metabolic reprogramming as a mechanism controlling the transition of precursor T cells to terminally exhausted T cells in chronic infections and cancer.