Abby E. Odle

This study investigates the role of I proteins from hCoV-HKU1 and hCoV-OC43 in pathogenesis using a prototypic coronavirus, finding that hCoV-HKU1 I protein reduces disease severity while MERS-CoV I protein exacerbates it.

This study identifies TRIM7 as an E3-ubiquitin ligase that ubiquitinates SARS-CoV-2 M protein to inhibit apoptosis and viral replication.

This study uses deep mutational scanning to analyze the SARS-CoV-2 spike fusion peptide, identifying mutations affecting viral entry and antibody resistance.

This study identifies S2 domain mutations in SARS-CoV-2 spike that reduce binding to antibodies, showing antigenic drift in this region and its impact on vaccine efficacy.