Dhananjay Kumar

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

This study investigates how the BRCA1-BARD1 complex interacts with chromatin containing specific histone modifications, showing it preferentially binds di-nucleosomes and uses multivalent interactions to overcome inhibitory marks.