Gillian Clifford

This study introduces an auxin-inducible degron system in Diplonema papillatum to enable conditional protein depletion and assesses its effects on key cellular processes.

This study examines how mutations in the PWWP domain of DNMT3A affect chromatin recruitment through different mechanisms, leading to distinct disease phenotypes.

This study identifies 17 proteins localized to the feeding apparatus and flagellar apparatus in Diplonema papillatum, providing foundational insights into their molecular mechanisms.

This study shows MeCP2 binds methylated DNA in nucleosomes via linker DNA interactions beyond its canonical methyl binding domain, revealing a new mechanism for chromatin DNA methylation recognition.

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.

This study investigates how the BRCA1-BARD1 complex interacts with chromatin containing specific histone modifications, showing it preferentially binds di-nucleosomes and uses multivalent interactions to overcome inhibitory marks.

This study identifies BARD1's role in recruiting BRCA1 to DNA damage sites via H2AK15ub binding, linking it to HR and pathway choice.