Denys A. Khaperskyy

This study shows influenza virus uses its nucleoprotein to block RIG-I activation by host RNAs, thereby suppressing the antiviral response and enhancing viral replication.

This paper shows that baloxavir resistance mutations in the PA protein impair host shutoff activity of PA-X, potentially limiting the spread of resistant influenza viruses.

The paper identifies sequence features in the TIAR 5' UTR that confer resistance to SARS-CoV-2 Nsp1 host shutoff, revealing shared characteristics with viral leader sequences.

This study shows that the NS1 effector domain is required for PA-X mediated host shutoff in influenza A virus, demonstrating functional interaction between these proteins.