María J. Marcaida

This study demonstrates the ability to detect and discriminate microcystin congeners at sub-nanomolar concentrations using aerolysin nanopores, with applications for environmental monitoring.

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

This study reveals how β-lactam antibiotics interact with the histidine kinase VbrK through redox-dependent cysteine acylation, enabling bacterial resistance.

This study identifies and characterizes nonlinear ion transport phenomena in β-barrel nanopores, linking lumen charge distribution to open-pore rectification and gating.

This study shows that Huntingtin (HTT) binds to F-actin, bundles actin filaments, and modulates the association of Drebrin1 with actin, affecting axonal growth and cytoskeletal organization in neurons.

This paper develops a high-throughput single-molecule FLIM technique using a time-gated single-photon camera, achieving precise lifetime measurements with spatial multiplexing of over 3000 molecules.

The paper explores new nanopore sensors from the aerolysin family by analyzing structure and sensing capabilities of three family members, finding ETX can translocate ssDNA with higher sensitivity than aerolysin.

The paper presents high-resolution cryo-EM structures of aerolysin pre-pore and pore in a membrane-like environment, revealing key interactions and constriction rings relevant for nanopore sensing.

The paper investigates missense mutations in PREPL in CMS22 patients, showing they affect non-hydrolytic functions without impairing hydrolase activity.

The paper examines how polyQ expansion affects HTT structure and phosphorylation, showing structural changes and altered phosphorylation patterns that influence HTT activity.