Matteo Dal Peraro

This study demonstrates the ability to detect and discriminate microcystin congeners at sub-nanomolar concentrations using aerolysin nanopores, with applications for environmental monitoring.

This study shows that CLIMP-63's luminal domain forms flexible trimers and its cytosolic tail mediates clustering, together determining ER sheet width.

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

This study reveals how β-lactam antibiotics interact with the histidine kinase VbrK through redox-dependent cysteine acylation, enabling bacterial resistance.

This study identifies and characterizes nonlinear ion transport phenomena in β-barrel nanopores, linking lumen charge distribution to open-pore rectification and gating.

This study investigates how cardiolipin dynamics influence mitochondrial membrane remodeling via OPA1 interactions using molecular dynamics and cryoEM.

This paper develops a high-throughput single-molecule FLIM technique using a time-gated single-photon camera, achieving precise lifetime measurements with spatial multiplexing of over 3000 molecules.

The paper explores new nanopore sensors from the aerolysin family by analyzing structure and sensing capabilities of three family members, finding ETX can translocate ssDNA with higher sensitivity than aerolysin.

This paper introduces RISoTTo, a geometric deep learning method for RNA sequence design that incorporates molecular context, showing improved accuracy and binding affinity in in silico tests.

This study identifies ACAD10 and ACAD11 as enzymes critical for metabolizing 4-hydroxy fatty acids in mammals, revealing their unique mechanisms and subcellular localization.

The paper presents high-resolution cryo-EM structures of aerolysin pre-pore and pore in a membrane-like environment, revealing key interactions and constriction rings relevant for nanopore sensing.

This study shows that EV-A71 adapts to heparan sulfate by losing pH-dependent uncoating, which compromises capsid stability and affects viral fitness in vivo.

This paper identifies membrane-bound OXA beta-lactamases in Acinetobacter spp. and shows they are secreted into outer membrane vesicles, contributing to antimicrobial resistance.

This study uses AR-SHS and current measurements to analyze aerolysin's membrane association and pore formation at femtomolar concentrations, revealing binding affinities and structural changes during the process.

The paper investigates how ESM-2, a protein language model, predicts protein contacts by analyzing coevolving residue statistics and local sequence context.

The paper investigates the structural arrangement of SNARE proteins in QabcR complexes and shows that structural exchange is tolerated but some non-cognate exchanges lead to imbalances.

The paper introduces a graph neural network for predicting protein-ligand interactions without structural data, achieving competitive performance using representation learning.

This study investigates how posttranslational modifications affect the membrane interaction and helical structure of the N-terminal fragment of the huntingtin protein.

The paper investigates missense mutations in PREPL in CMS22 patients, showing they affect non-hydrolytic functions without impairing hydrolase activity.

HandMol provides an immersive, collaborative molecular modeling tool using WebXR, AI, and HCI technologies, enabling natural interactions and real-time collaboration without specialized software.

MolecularWebXR enables multiuser VR/AR discussions about chemistry and biology in immersive environments accessible via web browsers and consumer devices.

MaD improves integrative modeling of large flexible macromolecular complexes by using conformation-invariant descriptors from cryo-EM data and molecular simulations.

PeSTo predicts protein interacting interfaces using a parameter-free geometric transformer that acts on atom labels, outperforming existing methods and enabling analysis of dynamic structural data.

The paper shows that specific protein-membrane interactions enhance the export of metallo-β-lactamases into outer membrane vesicles in Gram-negative bacteria.

The paper examines how polyQ expansion affects HTT structure and phosphorylation, showing structural changes and altered phosphorylation patterns that influence HTT activity.