Simone Rizzetto

This study performs a transcriptome-wide meta-analysis to identify determinants of immune checkpoint blockade response, finding that stromal factors, not cancer-cell intrinsic features, are key predictors across tumor types.

VDJView is a tool for analysing immune single-cell multi-omics data, integrating gene expression, immune receptors, and clinical metadata to identify antigen-specific gene signatures and clonal expansions.

VDJPuzzle 2.0 reconstructs full-length B-cell receptor sequences from scRNA-seq with high accuracy, validated against Sanger sequencing.

This study examines how sequencing depth and read length affect scRNA-seq data quality, finding that sufficient depth and length improve TCRβ reconstruction and gene expression accuracy in T cells.